CorrMut server - online prediction of co-evolving residues (correlated mutations)

CorrMut web server automatically predicts co-evolving residues (CERs, aka correlated mutations) in two protein families using mutual information and Monte Carlo simulations. It will automatically map results of predictions on PDB structures when available. Click here for example of output for class I tRNA sythetases vs correspond tRNAs (Ile,Leu,Val).

The general assumption is that the residues which interact in two proteins, will display pattern of correlated evolution. Program considers two sequences as an interacting pair that come in the same order in two input files. In each file sequences must be related. Program will perform multiple alignment, if required. If only one file is supplied, the correlated positions are sought within one multiple alignment.


For example:
File 1                File2
>gi_xxx               >gi_abc
MDNNQ     <-pair->    MASTN          
>gi_zzz               >gi_def
MANRQ     <-pair->    MLTTQ
...



Paste fasta sequence file 1 or multiple alignment in fasta or CLUSTALW format: Paste fasta sequence file 2 or multiple alignment in fasta or CLUSTALW format:
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